The pontiff was speaking to host Jordi Evole on the 'Salvados' programme broadcast on Spanish TV channel La Sexta when he was asked about people referring to Messi as 'God'.
Evole asked the Pope: 'Is it sacrilege to say that Messi is God?'
And Pope Francis replied: 'In theory it is sacrilege, you cannot say it, I don't believe. Do you believe you can?'
When Evole replied that he thought it was fine to say that, the pontiff, a native of Argentina like Messi, responded with a laugh and said: 'I don't.
'People say "God" like they say "I adore you". Adoring is only for God, they are expressions people use. "He is a god with a ball on the pitch", they are popular ways of expressing oneself.'
'But look how he plays, eh?' Evole responded.
The pope replied: 'Of course, he brings happiness, but he isn't God.'
The Pope has previously admitted to being a football fan and follows Argentine top-flight side San Lorenzo de Almagro.